Police can confirm one person has died in Waikato Hospital following the earlier collision on SH2 - Parry Palm Avenue, Waihi.
Police were alerted to the crash between a campervan and a car at about 2.24pm.
The person who has died had been travelling in the car at the time of the collision.
A second occupant from the car is reported to be in a serious condition in Waikato Hospital.
The road remains closed while Police examine the scene.
Diversions are in place.