Police are attending a crash at the intersection of Newtons Road and Dawsons Road in Templeton.
The crash involved a car and a truck towing a horse float.
Police were called at 10.17am.
Initial reports suggest two people received critical injuries and one person received serious injuries.
Two others received moderate injuries.
The road is blocked and motorists are advised to avoid the area if possible.
The Serious Crash Unit has been advised.
Issued by Police Media Centre