State Highway 27 is closed at Waharoa in the Matamata-Piako District following a serious crash.
Emergency services were called to the crash involving a truck and a car at 8.45pm.
Three people have been taken to Waikato Hospital, two in critical conditions and one in a serious condition.
The road is closed at Jagger Road and Walton Road.
The Serious Crash Unit is attending.
Issued by the Police Media Centre